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Details on Person PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

Class:IdReaction:9026408
_displayNamePTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3
_doReleaseTRUE
_timestamp2024-08-02 18:34:17
authored[InstanceEdit:9026397] Jassal, Bijay, 2017-10-19
catalystActivity[CatalystActivity:9026406] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of PTGS2 dimer [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9026397] Jassal, Bijay, 2017-10-19
crossReference[DatabaseIdentifier:9916753] RHEA:48853
edited[InstanceEdit:9026397] Jassal, Bijay, 2017-10-19
input[SimpleEntity:9608444] DPAn-3 [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:1131953] hydrogen donor [cytosol]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimericFALSE
literatureReference[LiteratureReference:9026402] Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections
[LiteratureReference:9026414] Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
modified[InstanceEdit:9027608] Jassal, Bijay, 2017-11-03
[InstanceEdit:9037607] Jassal, Bijay, 2018-02-20
[InstanceEdit:9037810] Jassal, Bijay, 2018-02-21
[InstanceEdit:9608447] Jassal, Bijay, 2018-05-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9916754] D'Eustachio, Peter, 2024-07-25
[InstanceEdit:9917366] D'Eustachio, Peter, 2024-08-02
namePTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
output[SimpleEntity:9026407] 13(R)-HDPAn-3 [cytosol]
[SimpleEntity:1130886] hydrogen acceptor [cytosol]
[SimpleEntity:29356] H2O [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2018-03-21
reviewed[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9026425] R-HSA-9026408.4
structureModified[InstanceEdit:9916754] D'Eustachio, Peter, 2024-07-25
summation[Summation:9026399] Incubation of ω-3 docosapentaenoic acid (DPAn-3) with human ...
(hasEvent)[Pathway:9025094] Biosynthesis of DPAn-3 SPMs [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9026411] 13(R)-HDPAn-3 translocates from endothelial cell to neutrophil [Homo sapiens]
[Reaction:9027598] Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779338] Update Tracker - [Reaction:9026408] PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 - v65:[add_removeInput]
[_UpdateTracker:9919487] Update Tracker - [Reaction:9026408] PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 - v90:[removeInput, removeOutput]
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