Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-...
| Class:Id | Summation:9026292 |
|---|---|
| _displayName | The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-... |
| _timestamp | 2018-02-21 11:36:06 |
| created | [InstanceEdit:9026287] Jassal, Bijay, 2017-10-19 |
| literatureReference | [LiteratureReference:9022657] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals |
| modified | [InstanceEdit:9026364] Jassal, Bijay, 2017-10-19 [InstanceEdit:9026548] Jassal, Bijay, 2017-10-20 [InstanceEdit:9037792] Jassal, Bijay, 2018-02-21 |
| text | The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-docosapentaenoic acid (DPAn-3) is an intermediate in the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) and is also a precursor for the production of novel bioactive mediators. The proposed biosynthesis of resolvins and protectins derived from DPAn-3 is described here (Dalli et al. 2013, Hansen et al. 2017, Vik et al. 2017). 15-lipoxygenase oxygenates DPAn-3 to its 17(S) hydroperoxy epimer from which resolvins and protectins are formed via a combination of oxygenation, reduction and hydrolysis reactions (Dalli et al. 2013). The products of the ω-3 isomer were characterised based on docosahexaenoic acid (DHA)-derived resolvins and protectins (Serhan et al. 2002) and were demonstrated to have similar potent systemic anti-inflammatory and tissue protective actions as DHA-derived specialised proresolving mediators (SPMs) (Dalli et al. 2013). The same biosynthetic route as DHA-derived SPMs is probably how DPAn-3 products are also formed (Dalli et al. 2013). |
| (summation) | [Pathway:9026286] Biosynthesis of DPAn-3-derived protectins and resolvins [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-... (9026292)
