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Details on Person IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

Class:Id	BlackBoxEvent:9025969
_displayName	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
_doRelease	TRUE
_timestamp	2018-01-03 20:54:48
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9025966] Jupe, Steve, 2017-10-16
edited	[InstanceEdit:9028790] Jupe, Steve, 2017-11-10
input	[Complex:1295546] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] [Homo sapiens] [DefinedSet:452094] STAT5A,STAT5B [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1266727] Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells [LiteratureReference:1266726] Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
modified	[InstanceEdit:9028799] Jupe, Steve, 2017-11-10 [InstanceEdit:9034318] D'Eustachio, Peter, 2018-01-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
output	[Complex:9025978] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1295519] IL7R is phosphorylated on Y499 [Homo sapiens] [BlackBoxEvent:8983063] JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1963543] Puck, J, 2011-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9025981] R-HSA-9025969.3
summation	[Summation:9025974] Signal transducer and activator of transcription 5A/B (STAT5...
(hasEvent)	[Pathway:1266695] Interleukin-7 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 [Homo sapiens]
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No pathways have been reviewed or authored by IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (9025969)