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Details on Person Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1

Class:Id	Reaction:9024973
_displayName	Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
_doRelease	TRUE
_timestamp	2018-02-21 13:57:16
authored	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
catalystActivity	[CatalystActivity:9025026] epoxide hydrolase activity of Epoxide hydrolase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
edited	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
input	[SimpleEntity:9025001] 13(S),14(S)-epoxy-DHA [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9024980] The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype [LiteratureReference:9024988] Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [LiteratureReference:9025004] The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells [LiteratureReference:9024984] Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain [LiteratureReference:9024996] Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages
modified	[InstanceEdit:9025027] Jassal, Bijay, 2017-10-11 [InstanceEdit:9026364] Jassal, Bijay, 2017-10-19 [InstanceEdit:9026540] Jassal, Bijay, 2017-10-20 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037604] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037805] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
output	[SimpleEntity:9025000] MaR1 [cytosol]
precedingEvent	[Reaction:9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA [Homo sapiens] [Reaction:9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9025022] R-HSA-9024973.2
summation	[Summation:9025002] Maresin 1 (MaR1, 7(R),14(S)-dihydroxy-docosahexaenoic acid) ...
(hasEvent)	[Pathway:9018682] Biosynthesis of maresins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9031802] Maresins translocate from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (9024973)