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Details on Person Maresins are a family of anti-inflammatory and pro-resolving...
| Class:Id | Summation:9024972 |
|---|---|
| _displayName | Maresins are a family of anti-inflammatory and pro-resolving... |
| _timestamp | 2017-12-04 11:27:07 |
| created | [InstanceEdit:9024999] Jassal, Bijay, 2017-10-11 |
| literatureReference | [LiteratureReference:9027020] Cellular and molecular basis of wound healing in diabetes [LiteratureReference:9026774] Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages |
| modified | [InstanceEdit:9026928] Jassal, Bijay, 2017-10-24 [InstanceEdit:9031795] Jassal, Bijay, 2017-12-04 |
| text | Maresins are a family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. In the first step, DHA is oxygenated by lipoxygenase 12 using Fe2+ cofactor (ALOX12:Fe2+) to 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) (Serhan et al. 2009, Deng et al. 2014). Maresin-like mediators MaR-L1 and Mar-L2 are produced by leukocytes and platelets and have been shown to restore reparative functions of diabetic macrophages in wounds (Brem & Tomic-Canic 2007, Hong et al. 2014). The same reaction as above can occur in human leukocytes and platelets to produce MaR-L1 and MaR-L2. The 14(S)-Hp-DHA intermediate can also serve as a precursor for maresin conjugates in tissue regeneration (MCTR) (Dalli et al. 2016). |
| (summation) | [Reaction:9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA [Homo sapiens] |
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