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Details on Person ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA

Class:Id	Reaction:9024881
_displayName	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA
_doRelease	TRUE
_timestamp	2018-02-26 18:02:22
authored	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
catalystActivity	[CatalystActivity:9022673] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
edited	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
input	[SimpleEntity:9024012] 17(S)-Hp-DHA [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9037793] Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages [LiteratureReference:9024475] Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation [LiteratureReference:9020266] Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms [LiteratureReference:9026926] The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation [LiteratureReference:9020250] Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
modified	[InstanceEdit:9026928] Jassal, Bijay, 2017-10-24 [InstanceEdit:9027542] Jassal, Bijay, 2017-11-02 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037600] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037792] Jassal, Bijay, 2018-02-21 [InstanceEdit:9037802] Jassal, Bijay, 2018-02-21 [InstanceEdit:9038365] D'Eustachio, Peter, 2018-02-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA
output	[SimpleEntity:9024873] 16S,17S-epoxy-DHA [cytosol] [SimpleEntity:29364] NADPH [cytosol]
precedingEvent	[Reaction:9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9024898] R-HSA-9024881.2
summation	[Summation:9024896] Instead of undergoing a second oxygenation (to form PDX), th...
(hasEvent)	[Pathway:9018677] Biosynthesis of DHA-derived SPMs [Homo sapiens]
(precedingEvent)	[Reaction:9024890] LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 [Homo sapiens] [Reaction:9026901] GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 [Homo sapiens]
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No pathways have been reviewed or authored by ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (9024881)