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Details on Person HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

Class:IdReaction:9024766
_displayNameHPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1
_doReleaseTRUE
_timestamp2024-08-02 19:05:07
authored[InstanceEdit:9024788] Jassal, Bijay, 2017-10-09
catalystActivity[CatalystActivity:2161623] 15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9024767] Jassal, Bijay, 2017-10-09
crossReference[DatabaseIdentifier:9916414] RHEA:50129
[DatabaseIdentifier:9916408] RHEA:50125
edited[InstanceEdit:9024788] Jassal, Bijay, 2017-10-09
input[SimpleEntity:9024764] RvD1 [cytosol]
[SimpleEntity:29360] NAD+ [cytosol]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimericFALSE
literatureReference[LiteratureReference:9024464] Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation
modified[InstanceEdit:9024788] Jassal, Bijay, 2017-10-09
[InstanceEdit:9024851] Jassal, Bijay, 2017-10-09
[InstanceEdit:9037601] Jassal, Bijay, 2018-02-20
[InstanceEdit:9037808] Jassal, Bijay, 2018-02-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24
[InstanceEdit:9917369] D'Eustachio, Peter, 2024-08-02
nameHPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1
NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH
NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH
output[DefinedSet:9024799] 17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1 [cytosol]
[SimpleEntity:73473] NADH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2018-03-21
reviewed[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9024778] R-HSA-9024766.3
structureModified[InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24
summation[Summation:9024762] Cytosolic, dimeric 15-hydroxyprostaglandin dehydrogenase (HP...
(hasEvent)[Pathway:9018676] Biosynthesis of D-series resolvins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9919497] Update Tracker - [Reaction:9024766] HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 - v90:[removeOutput]
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