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Details on Person Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz...
| Class:Id | Summation:9024761 |
|---|---|
| _displayName | Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz... |
| _timestamp | 2017-11-10 16:23:11 |
| created | [InstanceEdit:9024767] Jassal, Bijay, 2017-10-09 |
| literatureReference | [LiteratureReference:9022653] Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators [LiteratureReference:266036] Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes |
| modified | [InstanceEdit:9028817] Jassal, Bijay, 2017-11-10 |
| text | Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(S)-triHDHA and 7(S), 16(R), 17(S)-triHDHA (RvD1 and RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008). |
| (summation) | [Reaction:9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 [Homo sapiens] |
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