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Details on Person LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1

Class:Id	Reaction:9024726
_displayName	LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
_doRelease	TRUE
_timestamp	2018-08-14 15:55:16
authored	[InstanceEdit:9024742] May, Bruce, 2017-10-09
catalystActivity	[CatalystActivity:9024744] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643433] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9024729] May, Bruce, 2017-10-09
edited	[InstanceEdit:9024742] May, Bruce, 2017-10-09
inferredFrom	[Reaction:9030353] Lyn phosphorylates Crkl in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Crkl:Rapgef1 [Mus musculus]
input	[Complex:9024721] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9024736] CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling
modified	[InstanceEdit:9027279] May, Bruce, 2017-10-29 [InstanceEdit:9027297] May, Bruce, 2017-10-29 [InstanceEdit:9028860] May, Bruce, 2017-11-11 [InstanceEdit:9030367] May, Bruce, 2017-11-27 [InstanceEdit:9616794] Matthews, Lisa, 2018-08-14 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
output	[Complex:9024731] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9024723] EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 [Homo sapiens] [Reaction:9006323] Phospho-JAK2 phosphorylates EPOR [Homo sapiens]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9024753] R-HSA-9024726.3
summation	[Summation:9030356] LYN, in a complex with EPOR, phosphorylates CRKL bound to RA...
(hasEvent)	[Pathway:9027284] Erythropoietin activates RAS [Homo sapiens]
(precedingEvent)	[Reaction:9027274] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 [Homo sapiens]
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No pathways have been reviewed or authored by LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (9024726)