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Details on Person Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex

Class:Id	Reaction:9024326
_displayName	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex
_doRelease	TRUE
_timestamp	2019-08-14 02:22:56
authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9024351] Shamovsky, Veronica, 2017-10-03
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
input	[Complex:9024349] ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] [Homo sapiens] [DefinedSet:9024383] NR1H3, NR1H2 ligands [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9024380] GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus [LiteratureReference:9609456] Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
modified	[InstanceEdit:9035218] Shamovsky, Veronica, 2018-01-18 [InstanceEdit:9609459] Shamovsky, Veronica, 2018-05-24 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9637777] Shamovsky, Veronica, 2019-02-19 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658282] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9658424] Shamovsky, Veronica, 2019-08-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex
output	[Complex:9024368] ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9024417] R-HSA-9024326.2
summation	[Summation:9024344] In macrophages, excess of cholesterol leads to the formation...
(hasEvent)	[Pathway:9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux [Homo sapiens]
(precedingEvent)	[Reaction:9024334] Co-repressor complex dissociates from the transcription unit of the ABCA1 gene [Homo sapiens] [BlackBoxEvent:9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 [Homo sapiens]
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No pathways have been reviewed or authored by Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (9024326)