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Details on Person ATP Binding Cassette Subfamily G Member 1 (ABCG1, formerly c...

Class:IdSummation:9024325
_displayNameATP Binding Cassette Subfamily G Member 1 (ABCG1, formerly c...
_timestamp2019-08-09 09:03:07
created[InstanceEdit:9024351] Shamovsky, Veronica, 2017-10-03
literatureReference[LiteratureReference:9024359] ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
[LiteratureReference:9024389] Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
[LiteratureReference:9024358] The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver
[LiteratureReference:194271] ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I
[LiteratureReference:9609407] Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
[LiteratureReference:9610009] Isolation and characterization of a mammalian homolog of the Drosophila white gene
[LiteratureReference:194245] Genomic sequence and structure of the human ABCG1 (ABC8) gene
[LiteratureReference:9610022] Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element
[LiteratureReference:9609994] Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene
[LiteratureReference:9610041] ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
[LiteratureReference:9609987] Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases
[LiteratureReference:9610001] Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation
[LiteratureReference:9024380] GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
[LiteratureReference:9657870] ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
[LiteratureReference:9657828] An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells
modified[InstanceEdit:9609410] Shamovsky, Veronica, 2018-05-24
[InstanceEdit:9610053] Shamovsky, Veronica, 2018-06-05
[InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03
[InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09
textATP Binding Cassette Subfamily G Member 1 (ABCG1, formerly called “white” and/or ABCG8) expression is induced upon activation of liver X receptors (LXRα/NR1H3 or LXRβ/NR1H2) (Sabol SL et al. 2005; Beyea MM et al. 2007). The ABCG1 gene has been mapped to chromosome 21q22.3 and multiple human ABCG1 transcripts have been detected resulting from different transcription initiation sites and alternative mRNA splicing (Croop JM et al 1997; Langmann T et al. 2000; Lorkowski S et al. 2001; Kennedy MA et al. 2001). Induction of ABCG1 expression by NR1H2,3 agonists likely involves the presence of multiple LXR response elements (LXRE) through the promoter region of the ABCG1 gene (Kennedy MA et al. 2001; Sabol SL et al. 2005; Uehara Y et al. 2007). Studies in ABCG1 knockout mice revealed that ABCG1 is primarily expressed in macrophages, endothelial cells, and lymphocytes. However, it is also found in Kupffer cells and hepatocytes (Kennedy MA et al. 2005). ABCG1 exhibits a tissue specific expression pattern with high expression levels of ABCG1 found in lung, brain, spleen, adrenal glands, heart and liver (Croop JM et al 1997; Klucken J et al. 2000). ABCG1 plays an important role in cholesterol efflux (Kennedy MA et al. 2005; Wang N et al. 2004). In contrast to ABCA1, which transports cholesterol to lipid-poor apolipoprotein acceptors, ABCG1 transports cholesterol to preformed high-density lipoprotein (HDL) particles. A synergistic relationship between ABCA1 and ABCG1 has been proposed, whereby ABCA1 promotes lipidation of lipid-poor apoproteins and thus generating HDL-like acceptors for ABCG1-mediated cholesterol efflux (Gelissen IC et al. 2006). Beyond a role in cellular lipid homeostasis, ABCG1 participates in glucose and lipid metabolism by controlling the secretion and activity of insulin and lipoprotein lipase (Sturek JM et al. 2010; Olivier M et al. 2012; Hardy LM et al. 2017).

G-protein pathway suppressor 2 (GPS2) was identified as a co-regulator required for NR1H2, NR1H3-induced transcription of the ABCG1 gene in human hepatic HepG2 and macrophage THP-1 cells (Jakobsson T et al. 2009).

(summation)[BlackBoxEvent:9024361] Expression of ABCG1 regulated by NR1H2,3 [Homo sapiens]
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