Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end

Class:Id	BlackBoxEvent:9023943
_displayName	MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end
_doRelease	TRUE
_timestamp	2017-09-29 09:33:07
authored	[InstanceEdit:913923] May, B, 2010-07-19
catalystActivity	[CatalystActivity:981788] 3'-5'-DNA exonuclease activity of MRN:CtIP [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643714] 3'-5'-exodeoxyribonuclease activity of MRN:CtIP [nucleoplasm] The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9023944] May, Bruce, 2017-09-29
edited	[InstanceEdit:913923] May, B, 2010-07-19
inferredFrom	[BlackBoxEvent:912357] Removal of Spo11 and Resection of 5' Ends of DNA [Mus musculus] [BlackBoxEvent:981784] Removal of SPO11 and Resection of 5' Ends of DNA (yeast) [Saccharomyces cerevisiae]
input	[Complex:9023945] SPO11:double strand break with 3' single strand breaks [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:913336] Human CtIP promotes DNA end resection
modified	[InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end Removal of SPO11 and Resection of 5' Ends of DNA
output	[Complex:912381] SPO11:oligonucleotide [nucleoplasm] [Homo sapiens] [OtherEntity:75156] 3' overhanging DNA at resected DSB ends [nucleoplasm]
precedingEvent	[BlackBoxEvent:9023941] MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 [Homo sapiens] [Reaction:912368] SPO11 hydrolyzes DNA forming double-strand breaks [Homo sapiens]
releaseDate	2011-03-15
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9023948] R-HSA-9023943.3
summation	[Summation:9023940] The MRN complex (MRE11:RAD50:NBS1:CtIP) exonucleolytically h...
(hasEvent)	[Pathway:912446] Meiotic recombination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:912503] Formation of meiotic single-stranded DNA invasion complex [Homo sapiens]
(replacementInstances)	[_Deleted:9023953] Deletion of instance: 912397
[Change default viewing format]

No pathways have been reviewed or authored by MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (9023943)