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Details on Person AGO2 cleaves passenger strand of duplex siRNA

Class:Id	Reaction:9023912
_displayName	AGO2 cleaves passenger strand of duplex siRNA
_doRelease	TRUE
_timestamp	2017-09-29 02:55:40
authored	[InstanceEdit:203918] Gopinathrao, G, May, B, 2007-11-18 23:55:40
catalystActivity	[CatalystActivity:2106608] RNA endonuclease activity of AGO2:duplex siRNA [cytosol]
catalystActivityReference	[CatalystActivityReference:9643359] endoribonuclease activity of AGO2:duplex siRNA [cytosol] Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9023908] May, Bruce, 2017-09-29
edited	[InstanceEdit:426442] May, B, 2009-06-10
input	[Complex:2106605] AGO2:duplex siRNA [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:203878] Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes [LiteratureReference:203914] RNA helicase A interacts with RISC in human cells and functions in RISC loading [LiteratureReference:210573] Argonaute2 is the catalytic engine of mammalian RNAi [LiteratureReference:426466] Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection [LiteratureReference:427814] Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells [LiteratureReference:427812] Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells [LiteratureReference:561218] Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells [LiteratureReference:1296406] ATP-dependent human RISC assembly pathways [LiteratureReference:2106617] Dicer is dispensable for asymmetric RISC loading in mammals [LiteratureReference:5600673] Structure of C3PO and mechanism of human RISC activation
modified	[InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AGO2 cleaves passenger strand of duplex siRNA
output	[Complex:9023915] AGO2:cleaved duplex siRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2106625] Duplex siRNA is loaded into Argonaute [Homo sapiens] [Reaction:426464] Dicer cleaves double-stranded RNA to yield double-stranded siRNA [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2106616] Tomari, Y, 2012-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9023917] R-HSA-9023912.3
summation	[Summation:426462] C3PO appears to act as a nuclease that hydrolyzes the passen...
(hasEvent)	[Pathway:426486] Small interfering RNA (siRNA) biogenesis [Homo sapiens]
(replacementInstances)	[_Deleted:9023924] Deletion of instance: 203934
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No pathways have been reviewed or authored by AGO2 cleaves passenger strand of duplex siRNA (9023912)