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Details on Person DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Class:Id	Reaction:9023633
_displayName	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
_doRelease	TRUE
_timestamp	2019-04-08 03:47:35
authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
catalystActivity	[CatalystActivity:8943774] serine-type endopeptidase activity of DPP4(1-766) [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9644113] serine-type endopeptidase activity of DPP4(1-766) [plasma membrane] Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9023634] May, Bruce, 2017-09-28
edited	[InstanceEdit:435259] May, B, 2009-09-09
input	[DefinedSet:381662] mature GLP1 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:508144] Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach [LiteratureReference:508103] Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum [LiteratureReference:508105] Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme [LiteratureReference:400541] Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
modified	[InstanceEdit:9644114] May, Bruce, 2019-04-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
output	[DefinedSet:400520] GLP-1 (Cleaved at N-terminus) [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:383313] Glucagon-like Peptide 1 is secreted from intestinal L cells [Homo sapiens] [BlackBoxEvent:381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9023636] R-HSA-9023633.3
summation	[Summation:400539] Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from th...
(hasEvent)	[Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) [Homo sapiens]
(replacementInstances)	[_Deleted:9023669] Deletion of instance: 400495
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