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Details on Person Insulin secretory granules translocate across the cortical actin network

Class:Id	BlackBoxEvent:9023204
_displayName	Insulin secretory granules translocate across the cortical actin network
_doRelease	TRUE
_timestamp	2018-01-14 07:16:34
authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
catalystActivity	[CatalystActivity:216854] microfilament motor activity of Myo5a [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
edited	[InstanceEdit:445324] May, B, 2009-10-29
input	[DefinedSet:216871] Insulin (at interior surface of cellular cortex). [secretory granule lumen] [Mus musculus]
literatureReference	[LiteratureReference:445570] Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells [LiteratureReference:445561] Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells [LiteratureReference:445572] Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation [LiteratureReference:445562] The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules [LiteratureReference:445565] MyRIP anchors protein kinase A to the exocyst complex [LiteratureReference:264260] Insulin vesicle release: walk, kiss, pause ... then run [LiteratureReference:8931605] MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway
modified	[InstanceEdit:9034904] May, Bruce, 2018-01-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Insulin secretory granules translocate across the cortical actin network
output	[DefinedSet:9023169] Insulin (post cortical actin network). [secretory granule lumen] [Mus musculus]
precedingEvent	[BlackBoxEvent:216852] Insulin secretory granule translocates to cell cortex [Mus musculus] [BlackBoxEvent:216806] Processing of Proinsulin to Insulin [Mus musculus]
releaseDate	2009-12-15
reviewed	[InstanceEdit:445324] May, B, 2009-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9023217] R-MMU-9023204.3
summation	[Summation:216840] Insulin-containing secretory granules are bound to Myosin Va...
(inferredFrom)	[BlackBoxEvent:9023171] Insulin secretory granule translocates across the cortical actin network [Homo sapiens]
(replacementInstances)	[_Deleted:9023241] Deletion of instance: 216855
(updatedInstance)	[_UpdateTracker:9780106] Update Tracker - [BlackBoxEvent:9023204] Insulin secretory granules translocate across the cortical actin network - v64:[removeCatalystActivity]
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No pathways have been reviewed or authored by Insulin secretory granules translocate across the cortical actin network (9023204)