Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))

Class:Id	Reaction:9023178
_displayName	PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))
_doRelease	TRUE
_timestamp	2019-02-14 13:09:19
authored	[InstanceEdit:9023203] May, Bruce, 2017-09-25
catalystActivity	[CatalystActivity:265209] serine-type endopeptidase activity of PCSK2 [secretory granule lumen]
compartment	[Compartment:1462052] secretory granule lumen
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
edited	[InstanceEdit:9023203] May, Bruce, 2017-09-25
inferredFrom	[Reaction:9023180] Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) [Homo sapiens] [BlackBoxEvent:216806] Processing of Proinsulin to Insulin [Mus musculus]
input	[SimpleEntity:351603] H2O [secretory granule lumen] [Complex:9023156] 6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:445484] Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2 [LiteratureReference:445504] Proinsulin conversion in GH3 cells after coexpression of human proinsulin with the endoproteases PC2 and/or PC3 [LiteratureReference:445525] Prohormone convertases (PC1/3 and PC2) in rat and human pancreas and islet cell tumors: subcellular immunohistochemical analysis [LiteratureReference:445479] Direct identification of prohormone conversion site in insulin-secreting cells [LiteratureReference:445540] Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
modified	[InstanceEdit:9637081] May, Bruce, 2019-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))
output	[Complex:264931] 6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:9023172] INS(57-89) [secretory granule lumen] [Homo sapiens]
precedingEvent	[Reaction:9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) [Homo sapiens] [Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9023208] R-HSA-9023178.3
summation	[Summation:9023167] PCSK2 (Prohormone Convertase 2) cleaves C-terminal to argini...
(hasEvent)	[Pathway:264876] Insulin processing [Homo sapiens]
(precedingEvent)	[Reaction:9023159] Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) [Homo sapiens]
(replacementInstances)	[_Deleted:9608312] Deletion of instance: 265179
[Change default viewing format]

No pathways have been reviewed or authored by PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (9023178)