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Details on Person Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)

Class:Id	Reaction:9023166
_displayName	Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)
_doRelease	TRUE
_timestamp	2017-11-13 05:03:35
authored	[InstanceEdit:9023203] May, Bruce, 2017-09-25
catalystActivity	[CatalystActivity:9023160] metallocarboxypeptidase activity of Cpe:Zn2+ [secretory granule membrane]
catalystActivityReference	[CatalystActivityReference:9643640] metallocarboxypeptidase activity of Cpe:Zn2+ [secretory granule membrane] The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
compartment	[Compartment:216813] secretory granule membrane
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
edited	[InstanceEdit:9023203] May, Bruce, 2017-09-25
input	[Complex:9023188] 2xHC-INS(25-56):4xHC-INS(57-110) [secretory granule lumen] [Homo sapiens] [SimpleEntity:351603] H2O [secretory granule lumen] [SimpleEntity:351603] H2O [secretory granule lumen]
isChimeric	TRUE
literatureReference	[LiteratureReference:9023179] The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
modified	[InstanceEdit:9023615] May, Bruce, 2017-09-28 [InstanceEdit:9028862] Matthews, Lisa, 2017-11-13 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)
output	[Complex:9023154] 2xHC-INS(25-54):4xHC-INS(57-110) [secretory granule lumen] [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stableIdentifier	[StableIdentifier:9023222] R-NUL-9023166.3
summation	[Summation:9023189] Carboxypeptidase E (also called Carboxypeptidase H) purified...
(inferredFrom)	[Reaction:9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) [Homo sapiens]
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No pathways have been reviewed or authored by Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54) (9023166)