Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)

Class:IdReaction:9023165
_displayNamePcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)
_doReleaseTRUE
_timestamp2017-11-13 05:04:03
authored[InstanceEdit:9023203] May, Bruce, 2017-09-25
catalystActivity[CatalystActivity:9023155] serine-type endopeptidase activity of Pcsk1:Ca2+ [secretory granule lumen]
catalystActivityReference[CatalystActivityReference:9643757] serine-type endopeptidase activity of Pcsk1:Ca2+ [secretory granule lumen] Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases
compartment[Compartment:1462052] secretory granule lumen
created[InstanceEdit:9023176] May, Bruce, 2017-09-27
edited[InstanceEdit:9023203] May, Bruce, 2017-09-25
input[Complex:265073] 6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens]
[SimpleEntity:351603] H2O [secretory granule lumen]
isChimericTRUE
literatureReference[LiteratureReference:9023153] Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases
[LiteratureReference:9023150] Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing
modified[InstanceEdit:9028862] Matthews, Lisa, 2017-11-13
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)
output[Complex:9023182] 6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens]
releaseDate2017-12-13
reviewed[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
[Species:48895] Rattus norvegicus
stableIdentifier[StableIdentifier:9023214] R-NUL-9023165.3
summation[Summation:9023206] Rat Pcsk1 cleaves C-terminal to arginine-56 in human proinsu...
(inferredFrom)[Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110) (9023165)
Follow Reactome