Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)

Class:Id	Reaction:9023163
_displayName	Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)
_doRelease	TRUE
_timestamp	2019-02-14 13:08:51
authored	[InstanceEdit:9023203] May, Bruce, 2017-09-25
catalystActivity	[CatalystActivity:9023195] metallocarboxypeptidase activity of CPE:Zn2+ [secretory granule membrane]
compartment	[Compartment:216813] secretory granule membrane
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
edited	[InstanceEdit:9023203] May, Bruce, 2017-09-25
inferredFrom	[Reaction:9023166] Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54) [Homo sapiens] [BlackBoxEvent:216806] Processing of Proinsulin to Insulin [Mus musculus]
input	[Complex:9023182] 6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens] [SimpleEntity:351603] H2O [secretory granule lumen] [SimpleEntity:351603] H2O [secretory granule lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:445512] Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity [LiteratureReference:445479] Direct identification of prohormone conversion site in insulin-secreting cells
modified	[InstanceEdit:9023615] May, Bruce, 2017-09-28 [InstanceEdit:9637081] May, Bruce, 2019-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)
output	[Complex:9023156] 6x2xHC-INS(25-54):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens]
precedingEvent	[Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens] [BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9023225] R-HSA-9023163.3
summation	[Summation:9023199] Carboxypeptidase E (CPE, also called Carboxypeptidase H) rem...
(hasEvent)	[Pathway:264876] Insulin processing [Homo sapiens]
(precedingEvent)	[Reaction:9023178] PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) [Homo sapiens]
(replacementInstances)	[_Deleted:9608312] Deletion of instance: 265179
[Change default viewing format]

No pathways have been reviewed or authored by Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (9023163)