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Details on Person Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fat...
| Class:Id | Summation:9022656 |
|---|---|
| _displayName | Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fat... |
| _timestamp | 2018-02-21 11:35:18 |
| created | [InstanceEdit:9022652] Jassal, Bijay, 2017-09-25 |
| literatureReference | [LiteratureReference:9018721] Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both? |
| modified | [InstanceEdit:9023654] Jassal, Bijay, 2017-09-28 [InstanceEdit:9028817] Jassal, Bijay, 2017-11-10 [InstanceEdit:9037792] Jassal, Bijay, 2018-02-21 |
| text | Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of E-series resolvins, one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017, Calder 2017). The initial transformation of EPA can be mediated by either cytochrome P450s and/or aspirin-acetylated cyclooxygenase-2, resulting in stereospecific formation of 18(R)- and 18(S) E-resolvins. Combinations of oxidation, reduction and hydrolysis reactions determine the type of E-resolvin formed (RvE1, RvE2 or RvE3) (Serhan & Petasis 2011). Aspirin acetylation of cyclooxygenase isoforms results in changed activities. Acetylation of cyclooxygenase-1 results in its inhibition and thereby halting production of inflammatory mediators. However, acetylation of cyclooxygenase-2 transforms its enzyme activity from a cyclooxygenase to a lipoxygenase, thereby blocking prostaglandin biosynthesis and, additionally, initiating the production of SPMs (Arita et al. 2005, Kyriakopoulos et al. 2017). The biosynthesis of 18(S) E-resolvins is described here. |
| (summation) | [Pathway:9018896] Biosynthesis of E-series 18(S)-resolvins [Homo sapiens] |
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No pathways have been reviewed or authored by Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fat... (9022656)
