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Details on Person PI3K is recruited to the estrogen receptors at the plasma me...
| Class:Id | Summation:9022154 |
|---|---|
| _displayName | PI3K is recruited to the estrogen receptors at the plasma me... |
| _timestamp | 2019-05-02 03:04:15 |
| created | [InstanceEdit:9022153] Rothfels, Karen, 2017-09-21 |
| modified | [InstanceEdit:9632144] Rothfels, Karen, 2018-12-14 [InstanceEdit:9632850] Rothfels, Karen, 2018-12-21 [InstanceEdit:9634617] Rothfels, Karen, 2019-01-11 [InstanceEdit:9637944] Rothfels, Karen, 2019-02-21 [InstanceEdit:9644996] Rothfels, Karen, 2019-05-02 |
| text | PI3K is recruited to the estrogen receptors at the plasma membrane by virtue of an estrogen-dependent interaction of the p85 regulatory subunit with the estrogen receptor. Estrogen stimulation increases PI3K activity in a manner that also depends on SRC and SRC kinase activity, and results in increased PIP3 production and activation of AKT signaling (Simoncini et al, 2000; Castoria et al, 2001; Castoria et al, 2012; Le Romancer et al, 2008). Activation of AKT signaling downstream of estrogen stimulation drives cellular proliferation through the upregulation of the G1/S cyclin CCND1 (Castoria et al, 2001; Castoria et al, 2004; reviewed in Castoria et al, 2010), and E2 is also required for recruitment of focal adhesion kinase (FAK, also known as PTK2) (Le Romancer et al, 2008). AKT activation additionally stimulates phosphorylation of eNOS at residue 1117, promoting NO release in endothelial cells (Simoncini et al, 2000; Haynes et al, 2000; Hisamoto et al, 2001; Li et al, 2003; Haynes et al, 2003; reviewed in Levin, 2011). |
| (summation) | [Reaction:9021660] PI3K binds membrane-associated estrogen receptors [Homo sapiens] |
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