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Details on Person PI3K binds membrane-associated estrogen receptors

Class:Id	Reaction:9021660
_displayName	PI3K binds membrane-associated estrogen receptors
_doRelease	TRUE
_timestamp	2019-05-02 03:06:53
authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9021659] Rothfels, Karen, 2017-09-19
input	[Complex:9021593] ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] [Homo sapiens] [Complex:198379] PI3K alpha [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9021578] Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9632116] Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells [LiteratureReference:9632130] Regulation of estrogen rapid signaling through arginine methylation by PRMT1 [LiteratureReference:9021572] Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells [LiteratureReference:9022139] Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells [LiteratureReference:9022151] Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells [LiteratureReference:9021563] Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen [LiteratureReference:9022155] Minireview: Extranuclear steroid receptors: roles in modulation of cell functions [LiteratureReference:9021005] Extranuclear steroid receptors are essential for steroid hormone actions [LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells
modified	[InstanceEdit:9022161] Rothfels, Karen, 2017-09-21 [InstanceEdit:9024124] Rothfels, Karen, 2017-09-29 [InstanceEdit:9632188] Rothfels, Karen, 2018-12-14 [InstanceEdit:9632870] Rothfels, Karen, 2018-12-21 [InstanceEdit:9637808] Rothfels, Karen, 2019-02-19 [InstanceEdit:9637943] Rothfels, Karen, 2019-02-21 [InstanceEdit:9645014] Rothfels, Karen, 2019-05-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K binds membrane-associated estrogen receptors
output	[Complex:9021654] ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9021609] ESR-associated SRC autophosphorylates [Homo sapiens] [Reaction:9021596] Membrane estrogen receptors bind SRC [Homo sapiens]
releaseDate	2019-03-20
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9021661] R-HSA-9021660.3
summation	[Summation:9022154] PI3K is recruited to the estrogen receptors at the plasma me...
(hasEvent)	[Pathway:9009391] Extra-nuclear estrogen signaling [Homo sapiens]
(precedingEvent)	[Reaction:9632412] PTK2 is recruited to methylated ESR1 [Homo sapiens] [Reaction:9632423] * can be added if more work on PBXIP done**ESR1 complex interacts with microtubules [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777811] Update Tracker - [Reaction:9021660] PI3K binds membrane-associated estrogen receptors - v69:[modifyText]
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No pathways have been reviewed or authored by PI3K binds membrane-associated estrogen receptors (9021660)