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Details on Person ESR-associated SRC autophosphorylates

Class:Id	Reaction:9021609
_displayName	ESR-associated SRC autophosphorylates
_doRelease	TRUE
_timestamp	2019-05-02 03:05:30
authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
catalystActivity	[CatalystActivity:9021588] protein tyrosine kinase activity of ESRs:STRN:ESTG:MyrG-SRC [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9021608] Rothfels, Karen, 2017-09-18
input	[Complex:9021587] ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9021563] Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen [LiteratureReference:9021578] Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9632116] Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells [LiteratureReference:9632130] Regulation of estrogen rapid signaling through arginine methylation by PRMT1
modified	[InstanceEdit:9021663] Rothfels, Karen, 2017-09-19 [InstanceEdit:9024074] Rothfels, Karen, 2017-09-29 [InstanceEdit:9632125] Rothfels, Karen, 2018-12-14 [InstanceEdit:9637808] Rothfels, Karen, 2019-02-19 [InstanceEdit:9637913] Rothfels, Karen, 2019-02-21 [InstanceEdit:9645004] Rothfels, Karen, 2019-05-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ESR-associated SRC autophosphorylates
output	[Complex:9021593] ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9021596] Membrane estrogen receptors bind SRC [Homo sapiens] [Reaction:9021600] G-proteins dissociate from plasma-membrane estrogen receptors [Homo sapiens] [BlackBoxEvent:9027670] ESTG binding induces ESR depalmitoylation [Homo sapiens]
releaseDate	2019-03-20
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9021610] R-HSA-9021609.3
summation	[Summation:9021658] Estrogen treatment stimulates autophosphorylation of SRC at ...
(hasEvent)	[Pathway:9009391] Extra-nuclear estrogen signaling [Homo sapiens]
(precedingEvent)	[Reaction:9021660] PI3K binds membrane-associated estrogen receptors [Homo sapiens]
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No pathways have been reviewed or authored by ESR-associated SRC autophosphorylates (9021609)