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Details on Person NOTCH3 binds WWP2

Class:IdReaction:9021520
_displayNameNOTCH3 binds WWP2
_doReleaseTRUE
_timestamp2017-11-02 15:30:56
authored[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
compartment[Compartment:70101] cytosol
created[InstanceEdit:9021525] Orlic-Milacic, Marija, 2017-09-18
edited[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
goBiologicalProcess[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
input[DefinedSet:9021530] NEXT3,NICD3 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:6807279] WWP2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9021528] Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer
modified[InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027529] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH3 binds WWP2
output[Complex:9021521] NEXT3,NICD3:WWP2 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2017-12-13
reviewed[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9021538] R-HSA-9021520.2
summation[Summation:9021533] WWP2, an E3 ubiquitin ligase, can interact with NOTCH3 cleav...
(hasEvent)[Pathway:9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[Reaction:9021523] WWP2 ubiquitinates NOTCH3 [Homo sapiens]
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