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Details on Person PBX1 gene transcription is directly stimulated by the NOTCH3...

Class:IdSummation:9021420
_displayNamePBX1 gene transcription is directly stimulated by the NOTCH3...
_timestamp2017-09-18 16:55:41
created[InstanceEdit:9021421] Orlic-Milacic, Marija, 2017-09-18
literatureReference[LiteratureReference:9021408] Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer
[LiteratureReference:9021423] Notch3 gene amplification in ovarian cancer
[LiteratureReference:9021439] Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
[LiteratureReference:9021437] The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials
[LiteratureReference:9021429] Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression
modified[InstanceEdit:9021427] Orlic-Milacic, Marija, 2017-09-18
[InstanceEdit:9021444] Orlic-Milacic, Marija, 2017-09-18
textPBX1 gene transcription is directly stimulated by the NOTCH3 coactivator complex (Park et al. 2008). NOTCH3 gene is amplified in high-grade ovarian serous carcinoma and NOTCH3 overexpression contributes to cancer cell growth (Park et al. 2006). Overexpression of NOTCH3 in high-grade ovarian serous carcinoma correlates with overexpression of PBX1 (Park et al. 2006, Park et al. 2008). PBX1 gene encodes a homeodomain transcription factor PBX1 which is a B cell leukemia (B-ALL) oncogene (Nourse et al. 1990, Kamps et al. 1991) and is also overexpressed in melanoma (Shiraishi et al. 2007).
(summation)[BlackBoxEvent:9021412] PBX1 gene expression is stimulated by NOTCH3 [Homo sapiens]
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