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Details on Person ZDHHC7, ZDHHC21 palmitoylate ESR1

Class:Id	Reaction:9021072
_displayName	ZDHHC7, ZDHHC21 palmitoylate ESR1
_doRelease	TRUE
_timestamp	2019-05-02 03:07:56
authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
catalystActivity	[CatalystActivity:9021069] protein-cysteine S-palmitoyltransferase activity of ZDHHC7, ZDHHC21 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:9021071] Rothfels, Karen, 2017-09-13
input	[SimpleEntity:200993] PALM-CoA [cytosol] [Complex:9021048] ESRs:HSBP1 oligomer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9021005] Extranuclear steroid receptors are essential for steroid hormone actions [LiteratureReference:9007401] Rapid steroid hormone actions via membrane receptors [LiteratureReference:9644989] Steroid hormone rapid signaling: the pivotal role of S-palmitoylation [LiteratureReference:9020996] S-palmitoylation modulates human estrogen receptor-alpha functions [LiteratureReference:9021000] Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol [LiteratureReference:9021013] A conserved mechanism for steroid receptor translocation to the plasma membrane [LiteratureReference:9021009] DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors
modified	[InstanceEdit:9022172] Rothfels, Karen, 2017-09-21 [InstanceEdit:9024126] Rothfels, Karen, 2017-09-29 [InstanceEdit:9637808] Rothfels, Karen, 2019-02-19 [InstanceEdit:9645024] Rothfels, Karen, 2019-05-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ZDHHC7, ZDHHC21 palmitoylate ESR1
output	[SimpleEntity:76194] CoA-SH [cytosol] [CandidateSet:9021061] PalmS-ESRs [cytosol] [Homo sapiens] [Polymer:5218689] HSBP1 oligomer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9021050] HSBP1 oligomer binds ESRs [Homo sapiens]
releaseDate	2019-03-20
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9021076] R-HSA-9021072.3
summation	[Summation:9021026] In addition to nuclear signaling, estrogen receptors also pr...
(hasEvent)	[Pathway:9009391] Extra-nuclear estrogen signaling [Homo sapiens]
(precedingEvent)	[Reaction:9021068] PalmS-ESRs bind CAVs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777700] Update Tracker - [Reaction:9021072] ZDHHC7, ZDHHC21 palmitoylate ESR1 - v69:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by ZDHHC7, ZDHHC21 palmitoylate ESR1 (9021072)