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Details on Person STAT5A dimer binds to importin subunits alpha-3(KPNA4), alph...
| Class:Id | Summation:9020777 |
|---|---|
| _displayName | STAT5A dimer binds to importin subunits alpha-3(KPNA4), alph... |
| _timestamp | 2017-09-11 15:45:49 |
| created | [InstanceEdit:9020739] Duenas, Corina, 2017-09-11 |
| literatureReference | [LiteratureReference:9020814] Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal |
| text | STAT5A dimer binds to importin subunits alpha-3(KPNA4), alpha-6(KPNA5) and beta-1(KPNB1). To determine if tyrosine-phosphorylated STAT5A has similar importin binding features, an in vitro binding assay was performed with STAT5a isolated from cells treated with epidermal growth factor (EGF) (supplementary material Fig. S1). STAT5a was immunoprecipitated from EGF treated cell lysates, and incubated with GST-importins. STAT5a from EGF-treated cells was found to bind importin-α3, importin-α6, and importin-β1. The binding to importin-β1 may indicate that tyrosine-phosphorylated STAT5a has an additional ability to bind importin-β1 (23704351). |
| (summation) | [CandidateSet:9020793] KPNA4,KPNA5 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by STAT5A dimer binds to importin subunits alpha-3(KPNA4), alph... (9020777)
