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Details on Person ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA

Class:Id	Reaction:9020274
_displayName	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA
_doRelease	TRUE
_timestamp	2018-02-21 13:41:50
authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9024992] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
input	[SimpleEntity:9024011] DHA [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9024988] Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [LiteratureReference:9024996] Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages
modified	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11 [InstanceEdit:9025027] Jassal, Bijay, 2017-10-11 [InstanceEdit:9027051] Jassal, Bijay, 2017-10-27 [InstanceEdit:9031795] Jassal, Bijay, 2017-12-04 [InstanceEdit:9037600] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037802] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA
output	[SimpleEntity:9025012] 14(S)-Hp-DHA [cytosol]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9020289] R-HSA-9020274.2
summation	[Summation:9024972] Maresins are a family of anti-inflammatory and pro-resolving...
(hasEvent)	[Pathway:9018677] Biosynthesis of DHA-derived SPMs [Homo sapiens]
(precedingEvent)	[Reaction:9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA [Homo sapiens] [Reaction:9024997] ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA [Homo sapiens] [Reaction:9027033] Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA [Homo sapiens]
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No pathways have been reviewed or authored by ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (9020274)