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Details on Person Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA

Class:Id	Reaction:9020261
_displayName	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA
_doRelease	TRUE
_timestamp	2018-02-21 13:53:10
authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:2161919] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
input	[SimpleEntity:9024011] DHA [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9022657] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals [LiteratureReference:9024464] Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation
modified	[InstanceEdit:9024471] Jassal, Bijay, 2017-10-04 [InstanceEdit:9024874] Jassal, Bijay, 2017-10-10 [InstanceEdit:9027559] Jassal, Bijay, 2017-11-02 [InstanceEdit:9029500] Jassal, Bijay, 2017-11-20 [InstanceEdit:9037600] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037804] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA
output	[SimpleEntity:9024522] 17(R)-Hp-DHA [cytosol]
precedingEvent	[Reaction:2314686] ASA- acetylates PTGS2 [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9020288] R-HSA-9020261.2
summation	[Summation:9024477] Normally, cyclooxygenases (COX) carry out stereospecific oxy...
(hasEvent)	[Pathway:9018677] Biosynthesis of DHA-derived SPMs [Homo sapiens]
(precedingEvent)	[Reaction:9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA [Homo sapiens] [Reaction:9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA [Homo sapiens]
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