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Details on Person ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA

Class:Id	Reaction:9020256
_displayName	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
_doRelease	TRUE
_timestamp	2018-02-21 13:46:05
authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9020578] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
input	[SimpleEntity:9024479] 7(S)-Hp-17(R)-HDHA [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9022657] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
modified	[InstanceEdit:9024471] Jassal, Bijay, 2017-10-04 [InstanceEdit:9024583] Jassal, Bijay, 2017-10-06 [InstanceEdit:9024788] Jassal, Bijay, 2017-10-09 [InstanceEdit:9024874] Jassal, Bijay, 2017-10-10 [InstanceEdit:9027542] Jassal, Bijay, 2017-11-02 [InstanceEdit:9037602] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037803] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
output	[SimpleEntity:9024602] 7S(8)-epoxy-17(R)-HDHA [cytosol] [SimpleEntity:29364] NADPH [cytosol]
precedingEvent	[Reaction:9020251] ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA [Homo sapiens] [Reaction:9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9020287] R-HSA-9020256.2
summation	[Summation:9024589] 5-lipoxygenase (ALOX5) possesses dual lipoxygenase activity ...
(hasEvent)	[Pathway:9020265] Biosynthesis of aspirin-triggered D-series resolvins [Homo sapiens]
(precedingEvent)	[Reaction:9020252] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 [Homo sapiens]
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No pathways have been reviewed or authored by ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (9020256)