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Details on Person Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz...
| Class:Id | Summation:9020254 |
|---|---|
| _displayName | Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz... |
| _timestamp | 2017-11-10 16:23:04 |
| created | [InstanceEdit:9020263] Jassal, Bijay, 2017-09-05 |
| literatureReference | [LiteratureReference:266036] Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes |
| modified | [InstanceEdit:9024874] Jassal, Bijay, 2017-10-10 [InstanceEdit:9024999] Jassal, Bijay, 2017-10-11 [InstanceEdit:9028817] Jassal, Bijay, 2017-11-10 |
| text | Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H may also be able to catalyse the hydrolysis of 17R(6)-epoxy-docosahexaenoic acid (17R(16)-epoxy-DHA) to 10(R),17(R)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid (aspirin-triggered (neuro)protectin D1, AT-(N)PD1) (Serhan et al. 2011). In human cells, AT-(N)PD1 decreased PMN migration as well as enhancing efferocytosis of apoptotic human PMN by macrophages, indicating AT-(N)PD1 as a potent anti-inflammatory proresolving molecule (Serhan et al. 2011). |
| (summation) | [Reaction:9020257] LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 [Homo sapiens] |
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No pathways have been reviewed or authored by Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz... (9020254)
