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Details on Person GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE

Class:Id	Reaction:9018868
_displayName	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE
_doRelease	TRUE
_timestamp	2018-02-21 14:06:45
authored	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9020570] phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
edited	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
input	[SimpleEntity:9020583] 18(S)-HpEPE [cytosol] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29450] GSH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9020573] Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase [LiteratureReference:9024472] Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury
modified	[InstanceEdit:9020476] Jassal, Bijay, 2017-09-06 [InstanceEdit:9020571] Jassal, Bijay, 2017-09-07 [InstanceEdit:9020588] Jassal, Bijay, 2017-09-07 [InstanceEdit:9023654] Jassal, Bijay, 2017-09-28 [InstanceEdit:9024471] Jassal, Bijay, 2017-10-04 [InstanceEdit:9028817] Jassal, Bijay, 2017-11-10 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037598] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037807] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE
output	[SimpleEntity:9020474] 18(S)-HEPE [cytosol] [SimpleEntity:111745] GSSG [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:9018874] CYP monooxygenates EPA to 18(S)-HpEPE [Homo sapiens] [Reaction:9018880] Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE [Homo sapiens] [Reaction:2314686] ASA- acetylates PTGS2 [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018945] R-HSA-9018868.2
summation	[Summation:9020495] In PMNs, cytosolic phospholipid hydroperoxide glutathione pe...
(hasEvent)	[Pathway:9018896] Biosynthesis of E-series 18(S)-resolvins [Homo sapiens]
(precedingEvent)	[Reaction:9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE [Homo sapiens] [Reaction:9020610] ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 [Homo sapiens]
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No pathways have been reviewed or authored by GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (9018868)