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Details on Person 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2

Class:Id	Reaction:9018867
_displayName	5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2
_doRelease	TRUE
_timestamp	2024-08-02 19:04:54
authored	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9022666] NADPH dehydrogenase activity of 5-HEDH [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
crossReference	[DatabaseIdentifier:9916417] RHEA:52025
edited	[InstanceEdit:9018893] Jassal, Bijay, 2017-09-05
input	[SimpleEntity:9020602] 5(S)-Hp-18(S)-HEPE [cytosol] [SimpleEntity:1131953] hydrogen donor [cytosol]
internalReviewed	[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
isChimeric	FALSE
literatureReference	[LiteratureReference:9020605] Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis [LiteratureReference:9023641] Resolvin E2 formation and impact in inflammation resolution [LiteratureReference:9023711] Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids
modified	[InstanceEdit:9022652] Jassal, Bijay, 2017-09-25 [InstanceEdit:9023654] Jassal, Bijay, 2017-09-28 [InstanceEdit:9023707] Jassal, Bijay, 2017-09-28 [InstanceEdit:9024874] Jassal, Bijay, 2017-10-10 [InstanceEdit:9027542] Jassal, Bijay, 2017-11-02 [InstanceEdit:9027559] Jassal, Bijay, 2017-11-02 [InstanceEdit:9028817] Jassal, Bijay, 2017-11-10 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037598] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037802] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24 [InstanceEdit:9917369] D'Eustachio, Peter, 2024-08-02
name	5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O
output	[SimpleEntity:9022650] 18(S)-RvE2 [cytosol] [SimpleEntity:1130886] hydrogen acceptor [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:9018858] ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE [Homo sapiens] [Reaction:9018868] GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018939] R-HSA-9018867.3
structureModified	[InstanceEdit:9916393] D'Eustachio, Peter, 2024-07-24
summation	[Summation:9022661] An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(S)-hydr...
(hasEvent)	[Pathway:9018896] Biosynthesis of E-series 18(S)-resolvins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919441] Update Tracker - [Reaction:9018867] 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 - v90:[add_removeInput, add_removeOutput]
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