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Details on Person RHOU binds effectors at the plasma membrane

Class:Id	Reaction:9018766
_displayName	RHOU binds effectors at the plasma membrane
_doRelease	TRUE
_timestamp	2021-04-15 13:46:10
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9018764] Orlic-Milacic, Marija, 2017-09-05
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9727277] Orlic-Milacic, Marija, 2021-04-15
input	[Complex:9019560] RHOU:GTP [plasma membrane] [Homo sapiens] [CandidateSet:9019558] RHOU effectors [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9679659] ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion [LiteratureReference:9693867] Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9035998] Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase [LiteratureReference:9693893] Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 [LiteratureReference:9693898] PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion [LiteratureReference:9726831] The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration [LiteratureReference:9727018] The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis [LiteratureReference:9727021] GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration [LiteratureReference:9727033] The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways
modified	[InstanceEdit:9019621] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9693877] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693880] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693890] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693895] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693905] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693910] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9694018] Orlic-Milacic, Marija, 2020-07-08 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715161] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9726810] Orlic-Milacic, Marija, 2021-04-12 [InstanceEdit:9726847] Orlic-Milacic, Marija, 2021-04-12 [InstanceEdit:9727019] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9727024] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9727037] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9727278] Orlic-Milacic, Marija, 2021-04-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RHOU binds effectors at the plasma membrane
output	[Complex:9019556] RHOU:GTP:RHOU effectors [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9018768] RHOU auto-activates [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9726808] Shepelev, Mikhail V, 2021-03-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018771] R-HSA-9018766.3
summation	[Summation:9693875] In its active GTP bound form, RHOU binds the following effec...
(hasEvent)	[Pathway:9013420] RHOU GTPase cycle [Homo sapiens]
(replacementInstances)	[_Deleted:9716816] Deletion of instance: 194894
(updatedInstance)	[_UpdateTracker:9776179] Update Tracker - [Reaction:9018766] RHOU binds effectors at the plasma membrane - v77:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by RHOU binds effectors at the plasma membrane (9018766)