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Details on Person COL10A1-defective collagen type X binds Integrin alpha2beta1

Class:Id	Reaction:9018706
_displayName	COL10A1-defective collagen type X binds Integrin alpha2beta1
_timestamp	2017-09-04 10:42:20
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9018707] Varusai, Thawfeek, 2017-09-04
disease	[Disease:9017625] Schmid metaphyseal chondrodysplasia
input	[Complex:114561] ITGA2:ITGB1 [plasma membrane] [Homo sapiens] [Polymer:9017603] Defective collagen type X network [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9017608] Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer [LiteratureReference:9017618] Metaphyseal chondrodysplasia type Schmid mutations are predicted to occur in two distinct three-dimensional clusters within type X collagen NC1 domains that retain the ability to trimerize
modified	[InstanceEdit:9018716] Varusai, Thawfeek, 2017-09-04
name	COL10A1-defective collagen type X binds Integrin alpha2beta1
normalReaction	[Reaction:2470555] Collagen type X binds Integrin alpha2beta1 [Homo sapiens]
output	[Complex:9018705] COL10A1-defective collagen type X network:Integrin alpha2beta1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9017620] Formation of defective COL10A1 collagen networks [Homo sapiens] [BlackBoxEvent:9017640] Secretion of abnormal COL10A1 collagens [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018714] R-HSA-9018706.1
summation	[Summation:9018709] The NC1 domains of collagen types VII and X interact with in...
(hasEvent)	[Pathway:9018670] Abnormal integrin cell surface interactions [Homo sapiens]
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No pathways have been reviewed or authored by COL10A1-defective collagen type X binds Integrin alpha2beta1 (9018706)