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Details on Person COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1

Class:Id	Reaction:9018668
_displayName	COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
_timestamp	2017-09-04 09:49:05
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9018667] Varusai, Thawfeek, 2017-09-04
disease	[Disease:3656228] Ehlers-Danlos syndrome
input	[DefinedSet:444996] Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] [Homo sapiens] [DefinedSet:9018666] COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2327702] Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1 [LiteratureReference:2167979] Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains [LiteratureReference:4084783] Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains [LiteratureReference:4084771] The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix [LiteratureReference:4084747] Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin) [LiteratureReference:9014027] Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria [LiteratureReference:9014031] Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I
modified	[InstanceEdit:9018675] Varusai, Thawfeek, 2017-09-04
name	COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
normalReaction	[Reaction:2327695] Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 [Homo sapiens]
output	[Complex:9018665] COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] [Homo sapiens]
precedingEvent	[Polymerisation:9014269] Formation of defective COL5A1 collagen fibrils [Homo sapiens] [Reaction:9014217] Removal of defective COL5A1 fibrillar collagen N - propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018674] R-HSA-9018668.1
summation	[Summation:9018669] Integrin alpha10beta1 is able to bind collagen types I-VI, w...
(hasEvent)	[Pathway:9018670] Abnormal integrin cell surface interactions [Homo sapiens]
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No pathways have been reviewed or authored by COL5A1-defective collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (9018668)