Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) o...
| Class:Id | Summation:9018588 |
|---|---|
| _displayName | EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) o... |
| _timestamp | 2017-09-01 15:01:53 |
| created | [InstanceEdit:9018589] Orlic-Milacic, Marija, 2017-09-01 |
| text | EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) on an unknown tyrosine residue. EGFR signaling inhibits NICD3-mediated transcription. It is not known whether EGFR-mediated phosphorylation of NICD3 affects NICD3 nuclear translocation or the formation of the NOTCH3 coactivator complex. Erlotinib treatment, which inhibits EGFR activation, results in increased NOTCH3 signaling and induction of stem-like phenotype in treated cells (Arasada et al. 2014). |
| (summation) | [Reaction:9018572] EGFR phosphorylates NOTCH3 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) o... (9018588)
