Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NOTCH3 binds activated EGFR

Class:IdReaction:9018573
_displayNameNOTCH3 binds activated EGFR
_doReleaseTRUE
_timestamp2017-11-02 15:30:56
authored[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9018574] Orlic-Milacic, Marija, 2017-09-01
edited[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
goBiologicalProcess[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
input[Complex:179882] EGF:p-6Y-EGFR dimer [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:157647] NICD3 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9018571] EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
modified[InstanceEdit:9018586] Orlic-Milacic, Marija, 2017-09-01
[InstanceEdit:9018590] Orlic-Milacic, Marija, 2017-09-01
[InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027529] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH3 binds activated EGFR
output[Complex:9018569] EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2017-12-13
reviewed[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9018578] R-HSA-9018573.2
summation[Summation:9018587] The intracellular domain of NOTCH3 (NICD3) co-immunoprecipit...
(hasEvent)[Pathway:9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[Reaction:9018572] EGFR phosphorylates NOTCH3 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NOTCH3 binds activated EGFR (9018573)