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Details on Person EGFR phosphorylates NOTCH3

Class:IdReaction:9018572
_displayNameEGFR phosphorylates NOTCH3
_doReleaseTRUE
_timestamp2017-11-02 15:24:25
authored[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
catalystActivity[CatalystActivity:9018582] protein tyrosine kinase activity of EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643882] protein tyrosine kinase activity of EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9018574] Orlic-Milacic, Marija, 2017-09-01
edited[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
goBiologicalProcess[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
input[Complex:9018569] EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9018571] EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
modified[InstanceEdit:9018586] Orlic-Milacic, Marija, 2017-09-01
[InstanceEdit:9018590] Orlic-Milacic, Marija, 2017-09-01
[InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEGFR phosphorylates NOTCH3
output[Complex:179882] EGF:p-6Y-EGFR dimer [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9018581] p-Y-NICD3 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2017-12-13
reviewed[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9018577] R-HSA-9018572.3
summation[Summation:9018588] EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) o...
(hasEvent)[Pathway:9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
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No pathways have been reviewed or authored by EGFR phosphorylates NOTCH3 (9018572)