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Details on Person Type V collagen is digested by MMP2, MMP10, and MMP9. Mutati...
| Class:Id | Summation:9018353 |
|---|---|
| _displayName | Type V collagen is digested by MMP2, MMP10, and MMP9. Mutati... |
| _timestamp | 2017-09-06 10:06:02 |
| created | [InstanceEdit:9018358] Varusai, Thawfeek, 2017-08-31 |
| modified | [InstanceEdit:9018365] Varusai, Thawfeek, 2017-08-31 [InstanceEdit:9020462] Varusai, Thawfeek, 2017-09-06 |
| text | Type V collagen is digested by MMP2, MMP10, and MMP9. Mutations in procollagen peptide type V (COL5A1) can cause diseases such as Ehlers-Danlos Sydrome. Majority of the cases result from haploinsufficiency of COL5A1 protein that may lead to a disorganised extracellular matrix. Moreover, other mutations result in structural defects which may in turn result in defective collagen fibrils. The accumulation and interaction of this defective collagen fibrils may lead to ER stress and other complications in the cell (Takahara K et al. 2002, Symoens S et al. 2012). |
| (summation) | [Reaction:9018351] COL5A1-defective collagen type V degradation by MMP2,9,10 [Homo sapiens] |
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No pathways have been reviewed or authored by Type V collagen is digested by MMP2, MMP10, and MMP9. Mutati... (9018353)
