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Details on Person COL5A1-defective collagen type V degradation by MMP2,9,10

Class:Id	Reaction:9018351
_displayName	COL5A1-defective collagen type V degradation by MMP2,9,10
_timestamp	2017-08-31 10:31:25
catalystActivity	[CatalystActivity:2470134] metalloendopeptidase activity of MMP2,9,10 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9018358] Varusai, Thawfeek, 2017-08-31
disease	[Disease:3656228] Ehlers-Danlos syndrome
input	[Polymer:9014266] Defective collagen type V fibril [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161248] MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis [LiteratureReference:1474211] Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases [LiteratureReference:9014027] Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria [LiteratureReference:9014031] Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I
modified	[InstanceEdit:9018365] Varusai, Thawfeek, 2017-08-31
name	COL5A1-defective collagen type V degradation by MMP2,9,10
normalReaction	[Reaction:1564164] Collagen type V degradation by MMP2,9,10 [Homo sapiens]
output	[Polymer:9018352] Cleaved COL5A1-defective collagen type V fibril [extracellular region] [Homo sapiens]
precedingEvent	[Polymerisation:9014269] Formation of defective COL5A1 collagen fibrils [Homo sapiens] [Reaction:9014217] Removal of defective COL5A1 fibrillar collagen N - propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018361] R-HSA-9018351.1
summation	[Summation:9018353] Type V collagen is digested by MMP2, MMP10, and MMP9. Mutati...
(hasEvent)	[Pathway:9018210] Abnormal collagen degradation [Homo sapiens]
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No pathways have been reviewed or authored by COL5A1-defective collagen type V degradation by MMP2,9,10 (9018351)