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Details on Person COL1A1-defective collagen type I degradation by MMP1,2,8,13, PRSS2

Class:Id	Reaction:9018206
_displayName	COL1A1-defective collagen type I degradation by MMP1,2,8,13, PRSS2
_timestamp	2017-08-30 13:49:42
catalystActivity	[CatalystActivity:1605829] metalloendopeptidase activity of MMP1,2,8,13, PRSS2 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9018209] Varusai, Thawfeek, 2017-08-30
disease	[Disease:9015256] osteogenesis imperfecta
input	[Polymer:9015567] Defective COL1A1 collagen type I fibril [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1458414] The collagen substrate specificity of human skin fibroblast collagenase [LiteratureReference:1458399] The collagen substrate specificity of human neutrophil collagenase [LiteratureReference:1458404] Biochemical characterization of human collagenase-3 [LiteratureReference:1474194] Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments [LiteratureReference:1454859] Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis [LiteratureReference:9015589] Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans [LiteratureReference:9015250] The human type I collagen mutation database
modified	[InstanceEdit:9018217] Varusai, Thawfeek, 2017-08-30
name	COL1A1-defective collagen type I degradation by MMP1,2,8,13, PRSS2
normalReaction	[Reaction:1454822] Collagen type I degradation by MMP1,2,8,13, PRSS2 [Homo sapiens]
output	[Polymer:9018207] Cleaved defective COL1A1 collagen type I fibril [extracellular region] [Homo sapiens]
precedingEvent	[Polymerisation:9015584] Formation of defective COL1A1 collagen fibrils [Homo sapiens] [Reaction:2002440] Removal of fibrillar collagen C-propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018212] R-HSA-9018206.1
summation	[Summation:9018208] MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP...
(hasEvent)	[Pathway:9018210] Abnormal collagen degradation [Homo sapiens]
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No pathways have been reviewed or authored by COL1A1-defective collagen type I degradation by MMP1,2,8,13, PRSS2 (9018206)