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Details on Person COMP binds COL1A1-defective collagen, fibronectin, aggrecan and matrilins

Class:Id	Reaction:9018188
_displayName	COMP binds COL1A1-defective collagen, fibronectin, aggrecan and matrilins
_timestamp	2017-08-30 11:23:20
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9018186] Varusai, Thawfeek, 2017-08-30
disease	[Disease:9015256] osteogenesis imperfecta
input	[Complex:2426264] COMP pentamer [extracellular region] [Homo sapiens] [DefinedSet:9018187] COMP interactors with COL1A1-defective collagen I [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2299622] Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen [LiteratureReference:2426246] Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX [LiteratureReference:2426330] Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin [LiteratureReference:2426306] Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias [LiteratureReference:2299634] Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation [LiteratureReference:2426295] Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan [LiteratureReference:9015589] Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans [LiteratureReference:9015250] The human type I collagen mutation database
modified	[InstanceEdit:9018193] Varusai, Thawfeek, 2017-08-30
name	COMP binds COL1A1-defective collagen, fibronectin, aggrecan and matrilins
normalReaction	[Reaction:2424252] COMP binds collagen, fibronectin, aggrecan and matrilins [Homo sapiens]
output	[Complex:9018189] COMP pentamer:Abnormal COMP interactors [extracellular region] [Homo sapiens]
precedingEvent	[Polymerisation:9015584] Formation of defective COL1A1 collagen fibrils [Homo sapiens] [Reaction:2002440] Removal of fibrillar collagen C-propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018192] R-HSA-9018188.1
summation	[Summation:9018185] Cartilage oligomeric matrix protein (COMP, thrombospondin-5)...
(hasEvent)	[Pathway:9018137] Abnormal ECM proteoglycans [Homo sapiens]
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No pathways have been reviewed or authored by COMP binds COL1A1-defective collagen, fibronectin, aggrecan and matrilins (9018188)