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Details on Person SPARC binds COL1A1-defective collagen type I fibril, hydroxylapatite and Ca2+

Class:Id	Reaction:9018178
_displayName	SPARC binds COL1A1-defective collagen type I fibril, hydroxylapatite and Ca2+
_timestamp	2017-08-30 11:02:00
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9018177] Varusai, Thawfeek, 2017-08-30
disease	[Disease:9015256] osteogenesis imperfecta
input	[EntityWithAccessionedSequence:114643] SPARC [extracellular region] [Homo sapiens] [Polymer:9015567] Defective COL1A1 collagen type I fibril [extracellular region] [Homo sapiens] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:2672070] Hydroxylapatite [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:2672083] Immunoelectron microscopy of osteonectin and type I collagen in osteoblasts and bone matrix [LiteratureReference:9015589] Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans [LiteratureReference:9015250] The human type I collagen mutation database
modified	[InstanceEdit:9018183] Varusai, Thawfeek, 2017-08-30
name	SPARC binds COL1A1-defective collagen type I fibril, hydroxylapatite and Ca2+
normalReaction	[Reaction:2424243] SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ [Homo sapiens]
output	[Complex:9018180] COL1A1-defective collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] [Homo sapiens]
precedingEvent	[Polymerisation:9015584] Formation of defective COL1A1 collagen fibrils [Homo sapiens] [Reaction:2002440] Removal of fibrillar collagen C-propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018182] R-HSA-9018178.1
summation	[Summation:9018179] Secreted protein acidic and rich in cysteine (SPARC), also k...
(hasEvent)	[Pathway:9018137] Abnormal ECM proteoglycans [Homo sapiens]
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No pathways have been reviewed or authored by SPARC binds COL1A1-defective collagen type I fibril, hydroxylapatite and Ca2+ (9018178)