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Details on Person VTN binds COL5A1-defective collagens II, III and V

Class:Id	Reaction:9018168
_displayName	VTN binds COL5A1-defective collagens II, III and V
_timestamp	2017-08-30 10:46:19
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9018171] Varusai, Thawfeek, 2017-08-30
disease	[Disease:3656228] Ehlers-Danlos syndrome
input	[EntityWithAccessionedSequence:215971] VTN [extracellular region] [Homo sapiens] [DefinedSet:9018167] COL5A1-defective collagen types II, III, V [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2465880] Interaction of vitronectin with collagen [LiteratureReference:9014027] Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria [LiteratureReference:9014031] Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I
modified	[InstanceEdit:9018175] Varusai, Thawfeek, 2017-08-30
name	VTN binds COL5A1-defective collagens II, III and V Vitronectin binds COL5A1-defective collagens II, III and V
normalReaction	[Reaction:2396370] VTN binds collagens II, III and V [Homo sapiens]
output	[Complex:9018169] VTN:COL5A1-defective collagen types II,III,V [extracellular region] [Homo sapiens]
precedingEvent	[Polymerisation:9014269] Formation of defective COL5A1 collagen fibrils [Homo sapiens] [Reaction:9014217] Removal of defective COL5A1 fibrillar collagen N - propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018173] R-HSA-9018168.1
summation	[Summation:9018170] Vitronectin (VTN) is a major plasma glycoprotein of 75 kDa, ...
(hasEvent)	[Pathway:9018137] Abnormal ECM proteoglycans [Homo sapiens]
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No pathways have been reviewed or authored by VTN binds COL5A1-defective collagens II, III and V (9018168)