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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...
| Class:Id | Summation:9018124 |
|---|---|
| _displayName | Syndecans have attached heparan sulfate (HS) and to a lesser... |
| _timestamp | 2017-09-06 10:05:46 |
| created | [InstanceEdit:9018122] Varusai, Thawfeek, 2017-08-30 |
| modified | [InstanceEdit:9018132] Varusai, Thawfeek, 2017-08-30 [InstanceEdit:9020462] Varusai, Thawfeek, 2017-09-06 |
| text | Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins. HS chains facilitate interactions of syndecan-1 with extracellular matrix proteins, including several types of collagen. Mutations in procollagen peptide type V (COL5A1) can cause diseases such as Ehlers-Danlos Sydrome. Majority of the cases result from haploinsufficiency of COL5A1 protein that may lead to a disorganised extracellular matrix. Moreover, other mutations result in structural defects which may in turn result in defective collagen fibrils. The accumulation and interaction of this defective collagen fibrils may lead to ER stress and other complications in the cell (Takahara K et al. 2002, Symoens S et al. 2012). |
| (summation) | [Reaction:9018119] Syndecan-1 binds COL5A1-defective collagen types I, III, V [Homo sapiens] |
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No pathways have been reviewed or authored by Syndecans have attached heparan sulfate (HS) and to a lesser... (9018124)
