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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...
| Class:Id | Summation:9018123 |
|---|---|
| _displayName | Syndecans have attached heparan sulfate (HS) and to a lesser... |
| _timestamp | 2017-09-06 10:05:44 |
| created | [InstanceEdit:9018122] Varusai, Thawfeek, 2017-08-30 |
| modified | [InstanceEdit:9018132] Varusai, Thawfeek, 2017-08-30 [InstanceEdit:9020462] Varusai, Thawfeek, 2017-09-06 |
| text | Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins. HS chains facilitate interactions of syndecan-1 with extracellular matrix proteins, including several types of collagen. Type 1 collagen undergoes several intracellular and extracelluar process including its synthesis, processing and assembly into fibrils. Mutations in COL1A1 result in structurally defective type 1 collagen. This abnormal type 1 collagen forms non-functional fibrils, which eventually leads to disorders. COL1A1 mutations may lead to disorders such as osteogenesis imperfecta. Mutations in only one COL1A1 allele may cause a mild disease because of reduced normal type 1 collagen. Severe and lethal diseases occur when there are dominant negative mutations in COL1A1 producing structurally defective type 1 collagen. Most common mutations are glycine residue substitutions by larger amino acids, which affect the formation of collagen triple helix (Dalgleish R 1997, Gajko-Galicka et al. 2002). |
| (summation) | [Reaction:9018114] Syndecan-1 binds COL1A1-defective collagen types I, III, V [Homo sapiens] |
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No pathways have been reviewed or authored by Syndecans have attached heparan sulfate (HS) and to a lesser... (9018123)
