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Details on Person DDR1 binds COL5A1-defective collagen type I, II, III, IV, V, XI fibrils

Class:Id	Reaction:9018064
_displayName	DDR1 binds COL5A1-defective collagen type I, II, III, IV, V, XI fibrils
_timestamp	2017-08-29 09:44:35
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9018065] Varusai, Thawfeek, 2017-08-29
disease	[Disease:3656228] Ehlers-Danlos syndrome
input	[Complex:2327930] DDR1 dimer [plasma membrane] [Homo sapiens] [CandidateSet:9018066] COL5A1-defective collagen type I, II, III, IV, V, XI fibrils [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2327700] An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors [LiteratureReference:2465894] The discoidin domain receptor tyrosine kinases are activated by collagen [LiteratureReference:9014027] Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria [LiteratureReference:9014031] Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I
modified	[InstanceEdit:9018082] Varusai, Thawfeek, 2017-08-29
name	DDR1 binds COL5A1-defective collagen type I, II, III, IV, V, XI fibrils
normalReaction	[Reaction:2327738] DDR1 binds collagen type I, II, III, IV, V, XI fibrils [Homo sapiens]
output	[Complex:9018070] DDR1 dimer:COL5A1-defective collagen type I, II, III, IV, V, XI fibrils [plasma membrane] [Homo sapiens]
precedingEvent	[Polymerisation:9014269] Formation of defective COL5A1 collagen fibrils [Homo sapiens] [Reaction:9014217] Removal of defective COL5A1 fibrillar collagen N - propeptides [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9018081] R-HSA-9018064.1
summation	[Summation:9018074] Discoidin domain receptors (DDRs) are a subfamily of recepto...
(hasEvent)	[Pathway:9018067] Abnormal non-integrin membrane-ECM interactions [Homo sapiens]
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No pathways have been reviewed or authored by DDR1 binds COL5A1-defective collagen type I, II, III, IV, V, XI fibrils (9018064)