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Details on Person RB1 binds and inhibits E2F1/2/3:DP1/2 complexes

Class:IdReaction:9018017
_displayNameRB1 binds and inhibits E2F1/2/3:DP1/2 complexes
_doReleaseTRUE
_timestamp2020-05-19 11:32:24
authored[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
edited[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
input[EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens]
[Complex:1227905] E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:113709] Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
[LiteratureReference:9018028] The E2F transcription factor is a cellular target for the RB protein
[LiteratureReference:9018035] The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
[LiteratureReference:9018036] The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
[LiteratureReference:9018060] The retinoblastoma protein binds to a family of E2F transcription factors
[LiteratureReference:9018052] The E2F1-3 transcription factors are essential for cellular proliferation
[LiteratureReference:9018054] Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression
modified[InstanceEdit:9018025] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9018037] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9018063] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9028854] Orlic-Milacic, Marija, 2017-11-10
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9660676] Orlic-Milacic, Marija, 2019-09-11
[InstanceEdit:9687405] Orlic-Milacic, Marija, 2020-05-07
[InstanceEdit:9689391] Orlic-Milacic, Marija, 2020-05-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRB1 binds and inhibits E2F1/2/3:DP1/2 complexes
output[Complex:68644] RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9018018] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
[NegativeRegulation:9687404] Negative regulation by 'Cyclin E:p-T160-CDK2 [nucleoplasm]'
regulationReference[RegulationReference:9641568] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]' Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
releaseDate2004-07-06
reviewed[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9018020] R-HSA-9018017.6
summation[Summation:9018024] RB1 tumor suppressor, the product of the retinoblastoma susc...
(hasEvent)[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(normalReaction)[FailedReaction:9659782] Defective RB1 does not bind E2F1,(E2F2,E2F3) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777044] Update Tracker - [Reaction:9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - v73:[addRegulator]
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No pathways have been reviewed or authored by RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (9018017)
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