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Details on Person Based on studies in mice, association of MECP2 with the hype...

Class:IdSummation:9017923
_displayNameBased on studies in mice, association of MECP2 with the hype...
_timestamp2017-09-29 14:12:13
created[InstanceEdit:9017928] Orlic-Milacic, Marija, 2017-08-28
literatureReference[LiteratureReference:9017905] Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
[LiteratureReference:9017945] Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
[LiteratureReference:9017942] Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome
modified[InstanceEdit:9017948] Orlic-Milacic, Marija, 2017-08-28
[InstanceEdit:9017965] Orlic-Milacic, Marija, 2017-08-28
[InstanceEdit:9017969] Orlic-Milacic, Marija, 2017-08-29
[InstanceEdit:9024026] Orlic-Milacic, Marija, 2017-09-29
textBased on studies in mice, association of MECP2 with the hypermethylated OPRM1 gene promoter, encoding Mu-type opioid receptor (MOR), correlates with transcriptional repression of OPRM1 in the cerebellum. MECP2-mediated transcriptional repression of OPRM1 may be relieved by interaction of MECP2 with SMARCA4 (BRG1), a component of the chromatin remodeling SWI/SNF complex (Hwang et al. 2009). MECP2-mediated repression of OPRM1 involves the SIN3A co-repressor complex (Hwang et al. 2010). In the mouse model of MECP2 duplication syndrome, OPRM1 transcription in the amygdala and hippocampus is increased compared to wild-type mice (Samaco et al. 2012).
(summation)[BlackBoxEvent:9017921] OPRM1 gene expression is repressed by MECP2 [Homo sapiens]
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